Silver nanoparticles/ibuprofen-loaded poly(L-lactide) fibrous membrane: anti-infection and anti-adhesion effects.

Abstract

Infection caused by bacteria is one of the crucial risk factors for tendon adhesion formation. Silver nanoparticles (AgNP)-loaded physical barriers were reported to be effective in anti-infection and anti-adhesion. However, high silver load may lead to kidney and liver damages. This study was designed for Ibuprofen (IBU)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes containing a low dosage of Ag to evaluate its potential in maintaining suitable anti-infection and good anti-adhesion effects. The in vitro drug release study showed a sustained release of Ag ions and IBU from the membrane. Inferior adherence and proliferation of fibroblasts were found on the Ag4%-IBU4%-loaded PLLA electrospun fibrous membranes in comparison with pure PLLA and 4% Ag-loaded PLLA membranes. In the antibacterial test, all Ag-loaded PLLA electrospun fibrous membranes prevented the adhesion of Staphylococcus aureus and Staphylococcus epidermidis. Taken together, these results demonstrate that Ibuprofen is effective in enhancing the anti-adhesion and anti-proliferation effects of 4% Ag-loaded PLLA fibrous membrane. The medical potential of infection reduction and adhesion prevention of Ag4%-IBU4%-loaded PLLA electrospun fibrous membrane deserves to be further studied.

• Authors: Shuai Chen, Guangda Wang, Tianyi Wu, Xin Zhao, Shen Liu, Gang Li, Wenguo Cui, Cunyi Fan
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 15 Issue 8 Pg. 14014-25 (Aug 12 2014) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 25119863 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Carriers
• Polyesters
• Silver
• poly(lactide)
• Ibuprofen

Topics

• Animals
• Cell Adhesion (drug effects)
• Cell Line
• Cell Proliferation (drug effects)
• Drug Carriers (chemistry)
• Ibuprofen (chemistry, pharmacology)
• Metal Nanoparticles (chemistry, toxicity)
• Mice
• NIH 3T3 Cells
• Polyesters (chemistry)
• Silver (chemistry)
• Staphylococcus aureus (drug effects)
• Staphylococcus epidermidis (drug effects)