Abstract | BACKGROUND: METHODS: The multi-center, cross-sectional Chinese Bone Turnover Marker Study included 3800 healthy volunteers in 5 Chinese cities. Serum PINP, β-CTX, parathyroid hormone (PTH) and 25OHD levels were measured by chemiluminescence assay. Lumbar spine and proximal femur BMD were measured by dual-energy X-ray absorptiometry. Serum PINP and β-CTX levels were assessed by age, gender, weight, recruitment latitude, levels of PTH and 25OHD. RESULTS: Subjects (n = 1436, M: F, 500:936; mean age 50.6 ± 19.6 years) exhibited non-normally distributed PINP and β-CTX peaking between 15-19 years, gradually declining throughout adulthood, elevating within 10 years of postmenopause, and then declining by age 70. In women between the age of 30 and menopause, median PINP and β-CTX levels were 40.42 (95% CI: 17.10-102.15) and 0.26 (95% CI: 0.08-0.72) ng/mL, respectively. β-CTX and PINP were positively linearly correlated (r = 0.599, P<0.001). β-CTX correlated positively (r = 0.054 and 0.093) and PINP correlated negatively (r = -0.012 and -0.053) with 25OHD and PTH (P<0.05). CONCLUSIONS: We established Chinese reference ranges for PINP and CTX. Chinese individuals exhibited high serum PINP and β-CTX levels between 15 and 19 years of age and at menopause, which gradually declined after 70 years of age.
|
Authors | Mei Li, Yan Li, Weimin Deng, Zhenlin Zhang, Zhongliang Deng, Yingying Hu, Weibo Xia, Ling Xu |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 8
Pg. e103841
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25117452
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Biomarkers
- Collagen Type I
- Parathyroid Hormone
- Peptide Fragments
- Peptides
- Procollagen
- collagen type I trimeric cross-linked peptide
- procollagen Type I N-terminal peptide
- Calcifediol
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Altitude
- Biomarkers
(blood, metabolism)
- Body Weight
- Bone Density
- Bone and Bones
(metabolism)
- Calcifediol
(blood)
- China
- Collagen Type I
(blood, metabolism)
- Cross-Sectional Studies
- Female
- Healthy Volunteers
- Humans
- Male
- Middle Aged
- Parathyroid Hormone
(blood)
- Peptide Fragments
(blood, metabolism)
- Peptides
(blood, metabolism)
- Procollagen
(blood, metabolism)
- Reference Values
- Young Adult
|