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Chinese bone turnover marker study: reference ranges for C-terminal telopeptide of type I collagen and procollagen I N-terminal peptide by age and gender.

AbstractBACKGROUND:
Bone formation marker procollagen I N-terminal peptide (PINP) and resorption marker C-terminal telopeptide of type I collagen (β-CTX) are useful biomarkers for differential diagnosis and therapeutic evaluation of osteoporosis, but reference values are required.
METHODS:
The multi-center, cross-sectional Chinese Bone Turnover Marker Study included 3800 healthy volunteers in 5 Chinese cities. Serum PINP, β-CTX, parathyroid hormone (PTH) and 25OHD levels were measured by chemiluminescence assay. Lumbar spine and proximal femur BMD were measured by dual-energy X-ray absorptiometry. Serum PINP and β-CTX levels were assessed by age, gender, weight, recruitment latitude, levels of PTH and 25OHD.
RESULTS:
Subjects (n = 1436, M:F, 500:936; mean age 50.6 ± 19.6 years) exhibited non-normally distributed PINP and β-CTX peaking between 15-19 years, gradually declining throughout adulthood, elevating within 10 years of postmenopause, and then declining by age 70. In women between the age of 30 and menopause, median PINP and β-CTX levels were 40.42 (95% CI: 17.10-102.15) and 0.26 (95% CI: 0.08-0.72) ng/mL, respectively. β-CTX and PINP were positively linearly correlated (r = 0.599, P<0.001). β-CTX correlated positively (r = 0.054 and 0.093) and PINP correlated negatively (r =  -0.012 and -0.053) with 25OHD and PTH (P<0.05).
CONCLUSIONS:
We established Chinese reference ranges for PINP and CTX. Chinese individuals exhibited high serum PINP and β-CTX levels between 15 and 19 years of age and at menopause, which gradually declined after 70 years of age.
AuthorsMei Li, Yan Li, Weimin Deng, Zhenlin Zhang, Zhongliang Deng, Yingying Hu, Weibo Xia, Ling Xu
JournalPloS one (PLoS One) Vol. 9 Issue 8 Pg. e103841 ( 2014) ISSN: 1932-6203 [Electronic] United States
PMID25117452 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Collagen Type I
  • Parathyroid Hormone
  • Peptide Fragments
  • Peptides
  • Procollagen
  • collagen type I trimeric cross-linked peptide
  • procollagen Type I N-terminal peptide
  • Calcifediol
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Altitude
  • Biomarkers (blood, metabolism)
  • Body Weight
  • Bone Density
  • Bone and Bones (metabolism)
  • Calcifediol (blood)
  • China
  • Collagen Type I (blood, metabolism)
  • Cross-Sectional Studies
  • Female
  • Healthy Volunteers
  • Humans
  • Male
  • Middle Aged
  • Parathyroid Hormone (blood)
  • Peptide Fragments (blood, metabolism)
  • Peptides (blood, metabolism)
  • Procollagen (blood, metabolism)
  • Reference Values
  • Young Adult

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