Expression of Neural Wiskott-Aldrich Syndrome Protein in Clear Cell Renal Cell Carcinoma and Its Correlation with Clinicopathological Features.

Abstract

INTRODUCTION:

Neural Wiskott-Aldrich syndrome protein (N-WASP) expression is associated with tumor cell invasion and migration. However, its expression status in clear cell renal cell carcinoma (CCRCC) remains unclear. We examined the level of N-WASP in CCRCC and its association with clinicopathological features characteristic.

MATERIALS AND METHODS:

73 CCRCC patients who underwent radical nephrectomy or partial nephrectomy were enrolled. Immunohistochemical staining for N-WASP was performed on tissue microarrays constructed from tumor and para-tumor tissue obtained from these patients. The difference in N-WASP expression between tumor tissue and adjacent normal renal tissue was examined. Correlations between N-WASP expression in the tumor and clinicopathological parameters were analyzed and the relationship between N-WASP expression and overall survival also assessed. Uni- and multivariate survival analyses were performed.

RESULTS:

N-WASP expression was significantly reduced in tumor tissues and was significantly related to the histological grade of CCRCC. A higher level of N-WASP expression in the tumor was associated with relatively poor survival in CCRCC patients. The level of N-WASP expression, age at time of surgery, and histological grade were all responsible for clinical outcome in CCRCC patients. N-WASP was an independent predictor for overall survival.

CONCLUSIONS:

N-WASP was downregulated in CCRCC and could serve as a prognostic biomarker for predicting clinical outcome of CCRCC.

• Authors: Guang-Hua Liu, Jian Chen, Zhi-Gang Ji, Li Zhou
• Journal: Urologia internationalis (Urol Int) Vol. 95 Issue 1 Pg. 79-85 ( 2015) ISSN: 1423-0399 [Electronic] Switzerland
• PMID: 25115631 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 S. Karger AG, Basel.

Chemical References

• WASL protein, human
• Wiskott-Aldrich Syndrome Protein, Neuronal

Topics

• Aged
• Carcinoma, Renal Cell (diagnosis, metabolism, physiopathology)
• Down-Regulation
• Female
• Follow-Up Studies
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Humans
• Immunohistochemistry
• Kidney Neoplasms (diagnosis, metabolism, physiopathology)
• Male
• Middle Aged
• Multivariate Analysis
• Neoplasm Metastasis
• Nephrectomy
• Prognosis
• Proportional Hazards Models
• Tissue Array Analysis
• Treatment Outcome
• Wiskott-Aldrich Syndrome Protein, Neuronal (metabolism)