Combined use of monopolar radiofrequency and transdermal drug delivery in the treatment of melasma.

Abstract

BACKGROUND:

Melasma is a common acquired pigmentary disorder that has a considerable psychological impact on the patient. The recurrent and refractory nature of this condition makes it difficult for treatment.

OBJECTIVE:

We aim to evaluate the efficacy and safety of a combined system that simultaneously uses monopolar radiofrequency (RF) and transdermal drug delivery of phytocomplex containing 1% kojic acid in the treatment of melasma.

MATERIALS AND METHODS:

Fifty patients affected by melasma underwent 6 sessions of treatment at 1-week intervals. The outcome was evaluated before treatment (T0) and 1 month (T1) and 6 months (T2) after treatment using the Melasma Area and Severity Index score, a Mexameter, and Visioface devices for digital and ultraviolet computerized image analysis of skin color.

RESULTS:

The image analysis showed that hyperpigmentation was significantly reduced at T1 and T2 compared with baseline. Melasma Area and Severity Index score, the average melanin score, and the average erythema values showed a significant reduction. No side effects were observed or reported.

CONCLUSION:

This study describes the first report of improvement in melasma through the combined use of monopolar RF with transdermal delivery of depigmenting agents. This could be a safe, tolerable, and effective alternative tool for the treatment of melasma.

• Authors: Norma Cameli, Elva Abril, Maria Mariano, Enzo Berardesca
• Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 40 Issue 7 Pg. 748-55 (Jul 2014) ISSN: 1524-4725 [Electronic] United States
• PMID: 25111347 (Publication Type: Journal Article)

Chemical References

• Pyrones
• Skin Lightening Preparations
• kojic acid

Topics

• Adult
• Combined Modality Therapy (adverse effects)
• Erythema (etiology)
• Female
• Humans
• Image Processing, Computer-Assisted
• Melanosis (drug therapy, radiotherapy)
• Middle Aged
• Pyrones (administration & dosage, adverse effects)
• Radio Waves (adverse effects)
• Radiofrequency Therapy
• Severity of Illness Index
• Skin Lightening Preparations (administration & dosage, adverse effects)