The effect of pancreatic islet transplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic streptozocin-diabetic rats.

Abstract

The frequency of neuroaxonal dystrophy was determined in the superior mesenteric/celiac sympathetic ganglia in a streptozocin-treated rat model of diabetic autonomic neuropathy. Dystrophic axonopathy was increased 5- to 6-fold in 9-month untreated diabetics compared to age-matched controls. Pancreatic islet transplantation therapy or daily insulin administration prevented the development of dystrophic axonopathy. Transplantation of islets after 6 months of diabetes, a time at which dystrophic axonopathy is well developed, resulted in nearly complete resolution of the neuropathy within 3 months.

• Authors: R E Schmidt, S B Plurad, B J Olack, D W Scharp
• Journal: Brain research (Brain Res) Vol. 497 Issue 2 Pg. 393-8 (Sep 18 1989) ISSN: 0006-8993 [Print] Netherlands
• PMID: 2510903 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Insulin

Topics

• Animals
• Axons (drug effects, ultrastructure)
• Diabetes Mellitus, Experimental (drug therapy, pathology, surgery)
• Ganglia, Sympathetic (drug effects, pathology, ultrastructure)
• Insulin (therapeutic use)
• Islets of Langerhans Transplantation
• Male
• Microscopy, Electron
• Neurons (drug effects, pathology, ultrastructure)
• Rats
• Rats, Inbred WF
• Reference Values