Abstract | PURPOSE OF REVIEW: In recent years, immunosuppressive therapy, as an alternative to corticosteroids, has been proposed as novel agents which target the various antigens involved in the pathogenesis of Graves' ophthalmopathy. Although the lack of randomized and controlled studies suggests caution in generalizing results, some data show interesting results. RECENT FINDINGS: SUMMARY: Current clinical practice for Graves' ophthalmopathy will greatly benefit from the availability of immunosuppressors that act as disease-modifying drugs, as compared to steroids, the current standard treatment for Graves' ophthalmopathy. Rituximab seems to be a good candidate, as preliminary results from ongoing randomized trials suggest good efficacy with a relative well tolerated profile.
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Authors | Mario Salvi |
Journal | Current opinion in endocrinology, diabetes, and obesity
(Curr Opin Endocrinol Diabetes Obes)
Vol. 21
Issue 5
Pg. 409-14
(Oct 2014)
ISSN: 1752-2978 [Electronic] England |
PMID | 25105999
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antibodies, Blocking
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Tumor Necrosis Factor-alpha
- Rituximab
- Receptor, IGF Type 1
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Topics |
- Antibodies, Blocking
(immunology, pharmacology)
- Antibodies, Monoclonal
(immunology, pharmacology)
- Antibodies, Monoclonal, Murine-Derived
(pharmacology)
- Fibroblasts
(drug effects)
- Graves Ophthalmopathy
(drug therapy, immunology)
- Humans
- Immunotherapy
(methods)
- Inflammation
(drug therapy, immunology)
- Randomized Controlled Trials as Topic
- Receptor, IGF Type 1
(antagonists & inhibitors)
- Rituximab
- T-Lymphocytes
(drug effects, immunology)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
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