Abstract | INTRODUCTION AND OBJECTIVES: Total laryngectomy (TL) and postoperative radiotherapy (RT), when indicated, have proven to be effective in treating cases of locally advanced laryngeal cancer. The aim of this study was to analyse the oncological outcomes of this procedure in patients with laryngeal cancer classified T3 and T4a. METHODS: RESULTS: Mean age was 64 years with a male predominance (97%). As for habits, 96% were smokers and 89% consumed alcohol. Lymph node metastases occurred in 44% of patients and extracapsular invasion in 37% of them. All cases had tumour-free margins. In all, 25% of patients had loco-regional recurrence and 5% developed distant metastases. The 5-year disease-specific survival was 72% and 5-year overall survival was 55%. Variables associated with decreased disease-specific survival were T4 classification (P=.068), N2-N3 classifications (P=.005), extracapsular invasion (P=.018) and stage iv disease (P=.009). On multivariate analysis, the only variable associated with decreased disease-specific survival was the presence of N2-N3 nodal metastases (P=.008). CONCLUSIONS: TL is an effective treatment for the management of patients with locally advanced laryngeal cancer. Organ preservation protocols should achieve similar oncological results to those obtained with TL.
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Authors | Juan P Rodrigo, Fernando López, José L Llorente, César Álvarez-Marcos, Carlos Suárez |
Journal | Acta otorrinolaringologica espanola
(Acta Otorrinolaringol Esp)
2015 May-Jun
Vol. 66
Issue 3
Pg. 132-8
ISSN: 1988-3013 [Electronic] Spain |
Vernacular Title | Resultados de la laringectomía total en carcinoma localmente avanzado de laringe en la era de la organopreservación. |
PMID | 25103645
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier España, S.L.U. and Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial. All rights reserved. |
Topics |
- Adult
- Aged
- Aged, 80 and over
- Alcohol Drinking
(epidemiology)
- Carcinoma, Squamous Cell
(mortality, pathology, surgery)
- Female
- Humans
- Laryngeal Neoplasms
(mortality, pathology, surgery)
- Laryngectomy
(adverse effects, methods)
- Lymph Node Excision
- Lymphatic Metastasis
- Male
- Middle Aged
- Organ Sparing Treatments
(methods)
- Postoperative Complications
(etiology)
- Smoking
(epidemiology)
- Survival Analysis
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