Malondialdehyde, antioxidant enzymes, and renal tubular functions in children with iron deficiency or iron-deficiency anemia.

Abstract

We aimed to investigate the effects of iron deficiency (ID) or iron-deficiency anemia (IDA) on oxidative stress and renal tubular functions before and after treatment of children. A total of 30 children with a diagnosis of IDA constituted the IDA group and 32 children with a diagnosis of ID constituted the ID group. Control group consisted 38 age-matched children. Serum ferritin, soluble transferrin receptor (sTfR), serum, and urinary sodium (Na), potassium (K), calcium (Ca), phosphorus (P), creatinine (Cr), uric acid (UA), urinary N-acetyl-β-D-glucosaminidase (NAG) levels, and intra-erythrocyte malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) levels were measured before and after iron therapy in the IDA and ID groups, whereas it was studied once in the control group. We have divided the study group in groups according to age (infants <2 years, children 3-9 years, and adolescents 10-15 years). Patients with IDA (infant, adolescent) and ID (infant, children, and adolescent) had a significantly high level of MDA in post-treatment period in comparison to those of healthy control. Patients with IDA (children, adolescent) and ID (infant, children) had a significantly high level of pre-treatment GSH-Px than controls. Post-treatment SOD was lower in IDA (children and adolescent) groups than control and post-treatment CAT was lower in IDA and ID (adolescent) groups than control. These findings show that ferrous sulfate used in the treatment of ID or IDA could lead to oxidative stress; however, a marked deterioration of in proximal renal tubular functions was not seen.

• Authors: Demet Altun, Ahmet Emin Kurekci, Orhan Gursel, Duygu Ovunc Hacıhamdioglu, Ismail Kurt, Ahmet Aydın, Okan Ozcan
• Journal: Biological trace element research (Biol Trace Elem Res) Vol. 161 Issue 1 Pg. 48-56 (Oct 2014) ISSN: 1559-0720 [Electronic] United States
• PMID: 25099508 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Ferrous Compounds
• Receptors, Transferrin
• Phosphorus
• ferrous sulfate
• Malondialdehyde
• Ferritins
• Sodium
• Creatinine
• Iron
• Catalase
• Superoxide Dismutase
• Potassium
• Calcium

Topics

• Adolescent
• Anemia, Iron-Deficiency (blood, chemically induced, drug therapy)
• Antioxidants (metabolism)
• Calcium (blood, urine)
• Catalase (blood)
• Child
• Child, Preschool
• Creatinine (blood, urine)
• Deficiency Diseases (blood, drug therapy)
• Female
• Ferritins (blood)
• Ferrous Compounds (adverse effects, therapeutic use)
• Humans
• Infant
• Iron (blood)
• Iron Deficiencies
• Kidney Tubules (physiopathology)
• Male
• Malondialdehyde (blood)
• Outcome Assessment, Health Care (methods)
• Phosphorus (blood, urine)
• Potassium (blood, urine)
• Receptors, Transferrin (blood)
• Sodium (blood, urine)
• Superoxide Dismutase (blood)