Abstract | OBJECTIVE:
Anorexia nervosa is a psychiatric illness characterized by low weight, disordered eating, and hallmark neuroendocrine dysfunction. Behavioral phenotypes are defined by predominant restriction or bingeing/purging; binge-eating/purging type anorexia nervosa is associated with poorer outcome. The pathophysiology underlying anorexia nervosa types is unknown, but altered hormones, known to be involved in eating behaviors, may play a role. METHOD: RESULTS: Mean PYY 3-36 and leptin levels were lower and BDNF levels higher in binge-eating/purging type anorexia nervosa than in restricting type anorexia nervosa (all P values < .05). After controlling for body mass index, differences in PYY and PYY 3-36 between anorexia nervosa types were significant (P < .05) and differences in BDNF were at the trend level (P < .10). PYY 3-36 was positively (r = 0.27, P = .02) and leptin was negatively (r = -0.51, P < .0001) associated with dietary restraint; BDNF was positively associated with frequency of purging (r = 0.21, P = .04); and leptin was negatively associated with frequency of bingeing (r = -0.29, P = .007) and purging (r = -0.31, P = .004). CONCLUSIONS: Among women with anorexia nervosa, the anorexigenic hormones PYY, BDNF, and leptin are differentially regulated between the restricting and binge/purge types. Whether these hormone pathways play etiologic roles with regard to anorexia nervosa behavioral types or are compensatory merits further study.
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Authors | Kamryn T Eddy, Elizabeth A Lawson, Christina Meade, Erinne Meenaghan, Sarah E Horton, Madhusmita Misra, Anne Klibanski, Karen K Miller |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 76
Issue 1
Pg. 19-24
(Jan 2015)
ISSN: 1555-2101 [Electronic] United States |
PMID | 25098834
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © Copyright 2015 Physicians Postgraduate Press, Inc. |
Chemical References |
- Brain-Derived Neurotrophic Factor
- Leptin
- Peptide YY
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Topics |
- Adult
- Anorexia Nervosa
(blood, classification, epidemiology)
- Appetite
(physiology)
- Binge-Eating Disorder
(blood, epidemiology)
- Brain-Derived Neurotrophic Factor
(blood)
- Comorbidity
- Female
- Humans
- Leptin
(blood)
- Peptide YY
(blood)
- Young Adult
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