Abstract | AIM: The aim was to evaluate the risk of nephrotoxicity with high-dose, extended-interval regimen of colistin administration in critical ill patients. MATERIALS AND METHODS: This prospective study was conducted on patients suffering from sepsis due to Gram-negative infection susceptible only to colistin. The dosing schedule for colistin was 9 million units stat followed by 4.5 million units at 12 hourly interval (adjusted as per body weight and renal functions). The serum creatinine and creatinine clearance were estimated at the start of therapy and daily during therapy. RESULTS: CONCLUSION: Our study showed that high-dose, extended-interval colistin can be given to critically ill patients without any significant risk of nephrotoxicity.
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Authors | Arun Dewan, Mujeeb Shoukat |
Journal | Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
(Indian J Crit Care Med)
Vol. 18
Issue 7
Pg. 427-30
(Jul 2014)
ISSN: 0972-5229 [Print] India |
PMID | 25097354
(Publication Type: Journal Article)
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