HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Bisphosphonate use in children with pediatric osteoporosis and other bone conditions.

Abstract
Bisphosphonates (BPs) are used most commonly in children with osteogenesis imperfecta, resulting in increased trabeculae and cortical thickness, increased bone density as measured by DXA (Dual Energy X-ray Absorptiometry), and improved vertebral morphology. Less well documented in controlled trials are decrease in long bone fractures, improved strength and motor function, and decreased pain. Outside of children with osteogenesis imperfecta, use of bisphosphonates in children is increasing, all of which is off-label. This is seen in children with other chronic conditions resulting in pediatric osteoporosis and insufficiency fractures. Additional indications include steroid dependency with progressive loss of bone density, avascular necrosis of bone, and chronic regional pain syndrome. This review highlights the potential benefits and risks of the use of bisphosphonates in these unique children at risk for fracture or bone collapse.
AuthorsElizabeth A Szalay
JournalJournal of pediatric rehabilitation medicine (J Pediatr Rehabil Med) Vol. 7 Issue 2 Pg. 125-32 ( 2014) ISSN: 1875-8894 [Electronic] Netherlands
PMID25096864 (Publication Type: Journal Article, Review)
Chemical References
  • Diphosphonates
Topics
  • Absorptiometry, Photon
  • Bone Density (drug effects)
  • Child
  • Complex Regional Pain Syndromes (drug therapy)
  • Diphosphonates (therapeutic use)
  • Fractures, Bone (drug therapy, prevention & control)
  • Humans
  • Off-Label Use
  • Osteonecrosis (drug therapy)
  • Osteoporosis (drug therapy, prevention & control)
  • Pediatrics

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: