Abstract | INTRODUCTION:
Migraine is a very common medical disorder characterized by attacks of moderate-severe headache, nausea and disability. Topiramate is an effective, popular prophylactic migraine treatment, which is approved for use in adults and adolescents. Due to its multiple mechanisms of action, topiramate has multiple potential safety issues, including systemic and CNS adverse events, which may complicate therapy. AREAS COVERED: EXPERT OPINION:
Topiramate is highly effective in migraine prophylaxis but clinicians using the drug need to be aware of the potential for bothersome or serious adverse events. When treating with topiramate, use a slow titration to the goal dose of 100 mg or the lowest dose, which helps prevent migraine.
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Authors | Michael J Marmura |
Journal | Expert opinion on drug safety
(Expert Opin Drug Saf)
Vol. 13
Issue 9
Pg. 1241-7
(Sep 2014)
ISSN: 1744-764X [Electronic] England |
PMID | 25096056
(Publication Type: Journal Article, Review)
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Chemical References |
- Anticonvulsants
- Topiramate
- Fructose
|
Topics |
- Adolescent
- Adult
- Animals
- Anticonvulsants
(administration & dosage, adverse effects, therapeutic use)
- Cleft Lip
(chemically induced)
- Dose-Response Relationship, Drug
- Drug Interactions
- Female
- Fructose
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Humans
- Infant, Newborn
- Migraine Disorders
(drug therapy)
- Pregnancy
- Topiramate
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