Abstract | AIM: Adipose tissue Derived Mesenchymal Stem cells (ADMSCs) represent a promising toolfor new clinical concepts in supporting cellular therapy. The goal of this study was to investigate the effects of ADMSCs transplantation on oral ulcer healing in dogs. STUDY DESIGN: RESULTS: CONCLUSION: ADMSCs transplantation may help accelerate oral ulcer healing, possibly through the induction of angiogenesis by VEGF and PDGF as well as epithelial and connective tissue proliferation as evidenced by increased EGF and collagen gene expression.
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Authors | N M Alamoudi, E A El Ashiry, N M Farsi, D A El Derwi, H M Atta |
Journal | The Journal of clinical pediatric dentistry
(J Clin Pediatr Dent)
Vol. 38
Issue 3
Pg. 215-22
( 2014)
ISSN: 1053-4628 [Print] United States |
PMID | 25095315
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Glucocorticoids
- Platelet-Derived Growth Factor
- Vascular Endothelial Growth Factor A
- Epidermal Growth Factor
- Dexamethasone
- Collagen
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Topics |
- Adipose Tissue
(cytology)
- Animals
- Anti-Inflammatory Agents
(therapeutic use)
- Autografts
(transplantation)
- Biopsy
- Cell Culture Techniques
- Collagen
(analysis)
- Dexamethasone
(therapeutic use)
- Dogs
- Epidermal Growth Factor
(analysis)
- Glucocorticoids
(therapeutic use)
- Injections, Intralesional
- Lipectomy
(methods)
- Male
- Mesenchymal Stem Cell Transplantation
(methods)
- Neovascularization, Physiologic
(physiology)
- Oral Ulcer
(drug therapy, surgery)
- Platelet-Derived Growth Factor
(analysis)
- Re-Epithelialization
(physiology)
- Vascular Endothelial Growth Factor A
(analysis)
- Wound Healing
(physiology)
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