Imaging of rats with mammary cancer with two 2-deoxy-2-[18F]fluoro-D-hexoses.

Abstract

Rats with mammary cancer were imaged by scintigraphy: 10 rats with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and 10 rats with [18F]F-D-galactose. The uptake of both tracers was similar in the tumors--the tumor-to-normal tissue ratio was 2.7 +/- 1.1 for [18F]FDG and 2.3 +/- 0.9 for [18F]FDGal at 120 min after injection. In addition to the tumors [18F]FDG accumulated in the brain, bladder and heart, [18F]FDGal in the brain, bladder and liver. [18F]FDGal may be useful for tumor imaging in man; further studies should be addressed to elucidate the mechanism of [18F]FDGal uptake into tumors.

• Authors: R Paul, K Aho, J Bergman, M Haaparanta, J Kulmala, A Reissell, O Solin
• Journal: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology (Int J Rad Appl Instrum B) Vol. 16 Issue 5 Pg. 449-53 ( 1989) ISSN: 0883-2897 [Print] England
• PMID: 2509402 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fluorine Radioisotopes
• Fluorodeoxyglucose F18
• Fucose
• 9,10-Dimethyl-1,2-benzanthracene
• Deoxyglucose
• 2-deoxy-2-fluorogalactose
• Galactose

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Deoxyglucose (pharmacokinetics)
• Female
• Fluorine Radioisotopes
• Fluorodeoxyglucose F18
• Fucose (analogs & derivatives, pharmacokinetics)
• Galactose
• Mammary Neoplasms, Experimental (chemically induced, diagnostic imaging)
• Radionuclide Imaging
• Rats
• Rats, Inbred Strains