The effect of the antioxidant drug "U-74389G" on oophoritis during ischemia reperfusion injury in rats.

The aim of this experiment was to study the effects of the antioxidant drug "U-74389G" on rat model, particularly in ischemia reperfusion protocol. The beneficial or other effects of that molecule were studied estimating the mean oophoritis (OI) lesions.
40 rats were used of mean weight 231.875 g. OI was evaluated 60 min after reperfusion for groups A and C and 120 min after reperfusion for groups B and D. Groups A and B were without the drug but C and D with U-74389G administration. Results were that U-74389G administration kept non-significantly increased the OI scores by 0.05±0.051 without lesions (p=0.3204). Reperfusion time kept non-significantly increased the OI scores by 0.05±0.051 also without lesions (p=0.3204). Nevertheless, U-74389G administration and reperfusion time together kept non-significantly increased the OI scores by 0.045±0.030 (p=0.1334).
Results of this study indicate that U-74389G administration, reperfusion time and their interaction declined the increased OI scores from significant to non-significant level.
AuthorsConstantinos Τsompos, Constantinos Panoulis, Konstantinos Tauοutouzas, George Zetaografos, Apostolos Papalois
JournalAnti-inflammatory & anti-allergy agents in medicinal chemistry (Antiinflamm Antiallergy Agents Med Chem) Vol. 13 Issue 2 Pg. 103-7 ( 2014) ISSN: 1875-614X [Electronic] United Arab Emirates
PMID25091819 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Pregnatrienes
  • U 74389F
  • Animals
  • Antioxidants (pharmacology)
  • Disease Models, Animal
  • Female
  • Oophoritis (drug therapy)
  • Pregnatrienes (pharmacology)
  • Rats
  • Rats, Wistar
  • Reperfusion Injury (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: