Primary plasma cell leukemia: a case report of successful responder to a combination chemotherapy of vincristine, doxorubicin and dexamethasone.

Abstract

A patient with primary plasma cell leukemia is described. Immunoelectrophoresis revealed a monoclonal IgG/lambda protein and Bence Jones protein. Hematological data showed numerous immature plasma cells in peripheral blood and bone marrow. Cytogenetic study of tumor cells revealed a complex karyotypic abnormality. Subcutaneous involvement by tumor cells was found. The patient was treated with a combination of vincristine, doxorubicin, dexamethasone (VAD) and achieved a complete remission with disappearance of tumor cells, monoclonal protein and extramedullary involvement after 6 cycles of VAD. This regimen should be encouraged in treatment of primary plasma cell leukemia.

• Authors: M Suzuki, K Kawauchi, H Sugiyama, M Yasuyama, H Watanabe
• Journal: Acta haematologica (Acta Haematol) Vol. 82 Issue 2 Pg. 95-7 ( 1989) ISSN: 0001-5792 [Print] Switzerland
• PMID: 2508402 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vincristine
• Dexamethasone
• Doxorubicin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Dexamethasone (administration & dosage)
• Doxorubicin (administration & dosage)
• Humans
• Leukemia, Plasma Cell (drug therapy)
• Male
• Middle Aged
• Vincristine (administration & dosage)