Suspected primary hypoparathyroidism in a domestic ferret (Mustela putorius furo).

Abstract

CASE DESCRIPTION:

A 4-year-old castrated male domestic ferret (Mustela putorius furo) was examined because of a 3-week history of intermittent seizures, signs of depression, hypocalcemia, and hyperphosphatemia.

CLINICAL FINDINGS:

Plasma biochemical analysis confirmed hyperphosphatemia (17.7 mg/dL) and low concentrations of total (4.3 mg/dL) and ionized (0.49 mmol/L) calcium. Serum parathyroid hormone concentration (2.30 pmol/L) was low or in the low part of the reference interval.

TREATMENT AND OUTCOME:

Calcium gluconate was administered (2.0 mg/kg/h [0.9 mg/lb/h], IV), followed by a transition to administration of calcium carbonate (53 mg/kg [24.1 mg/lb], PO, q 12 h) and dihydrotachysterol (0.02 mg/kg/d [0.009 mg/lb/d], PO). Attitude of the ferret improved and seizures ceased as blood calcium concentrations increased. The ferret was reexamined because of seizures approximately 1 year after oral maintenance administration of dihydrotachysterol and calcium was initiated. The ferret responded well to emergency and long-term treatment but then was lost to follow-up monitoring. The ferret died approximately 2 years after the initial evaluation and treatment. Hypertrophic cardiomyopathy was diagnosed during necropsy, but the parathyroid glands could not be identified.

CLINICAL RELEVANCE:

To the authors' knowledge, primary hypoparathyroidism has not previously been reported in a ferret. The condition should be considered for ferrets with hypocalcemia and hyperphosphatemia without azotemia. Treatment with dihydrotachysterol and oral supplementation of calcium appeared to be a viable option for long-term management.

• Authors: Ricardo E de Matos, Maren J Connolly, Simon R Starkey, James K Morrisey
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 245 Issue 4 Pg. 419-24 (Aug 15 2014) ISSN: 1943-569X [Electronic] United States
• PMID: 25075826 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vitamins
• Calcium Carbonate
• Dihydrotachysterol
• Calcium Gluconate

Topics

• Animals
• Calcium Carbonate (administration & dosage, therapeutic use)
• Calcium Gluconate (administration & dosage, therapeutic use)
• Dihydrotachysterol (administration & dosage, therapeutic use)
• Ferrets
• Hypocalcemia (veterinary)
• Hypoparathyroidism (blood, drug therapy, veterinary)
• Male
• Vitamins (administration & dosage, therapeutic use)