Effect of topical aqueous suppression on intraocular gas duration after pure perfluoropropane injection in nonvitrectomized eyes with retinal detachment.

Abstract

PURPOSE:

To determine whether topical aqueous suppressants affect the duration of pure expansile intraocular gas in nonvitrectomized eyes.

METHODS:

A prospective randomized controlled trial was performed on nonvitrectomized patients undergoing retinal detachment repair with scleral buckle or pneumatic retinopexy using 0.3 mL of 100% perfluoropropane (C3F8) gas tamponade. Eyes were randomly assigned to receive topical dorzolamide 2% and timolol 0.5% twice daily postoperatively until gas dissolution or to observation.

RESULTS:

Twenty-one patients met all inclusion and exclusion criteria. Twelve were randomized to the control group and nine to the dorzolamide-timolol group. In the dorzolamide-timolol group, mean intraocular pressure was 17.4 on postoperative Day 1 and 12.5 on postoperative Week 1 (P = 0.03). In the control group, mean intraocular pressure was 14.5 on postoperative Day 1 and 15.1 on postoperative Week 1 (P = 0.73). The mean duration of C3F8 was 37.8 days in the dorzolamide-timolol group and 40.4 days in the control group (P = 0.70).

CONCLUSION:

Topical aqueous suppression does not seem to have a significant effect on the duration of pure expansile intraocular C3F8 in nonvitrectomized eyes after pneumatic retinopexy or scleral buckling.

• Authors: Jason Hsu, Adam T Gerstenblith, Nikolas J S London, Sunir J Garg, Marc J Spirn, Joseph I Maguire, Carl Park, Arunan Sivalingam
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 34 Issue 12 Pg. 2458-61 (Dec 2014) ISSN: 1539-2864 [Electronic] United States
• PMID: 25072647 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Drug Combinations
• Fluorocarbons
• Ophthalmic Solutions
• Sulfonamides
• Thiophenes
• Timolol
• dorzolamide
• perflutren

Topics

• Administration, Topical
• Adult
• Aged
• Antihypertensive Agents (pharmacology)
• Aqueous Humor (drug effects)
• Cryotherapy
• Drug Combinations
• Endotamponade
• Fluorocarbons (administration & dosage)
• Humans
• Injections, Intraocular
• Intraocular Pressure (drug effects)
• Middle Aged
• Ophthalmic Solutions
• Prospective Studies
• Retinal Detachment (surgery)
• Scleral Buckling
• Sulfonamides (pharmacology)
• Thiophenes (pharmacology)
• Time Factors
• Timolol (pharmacology)
• Vitrectomy