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[Possible mechanisms of Roux-en-Y gastric bypass treatment for type 2 diabetes mellitus].

Abstract
Roux-en-Y gastric bypass(RYGB) is a classic procedure for the treatment of type 2 diabetes mellitus (T2DM), but it remains unclear why this procedure works. There might be several mechanisms that RYGB works through to treat T2DM, including calorie restriction and malabsorption, improvement of insulin resistance and β-cell functions, and altered secretion of gastrointestinal hormones. Altered levels of adipokines and serum bile acids might also play a role after RYGB. Future researches should concentrate on the exact mechanism of the altered hormone levels after RYGB, and whether different methods of gastrointestinal tract reconstruction could lead to various hormone levels.
AuthorsGuanglong Dong, Xiao Xu
JournalZhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery (Zhonghua Wei Chang Wai Ke Za Zhi) Vol. 17 Issue 7 Pg. 737-40 (Jul 2014) ISSN: 1671-0274 [Print] China
PMID25070458 (Publication Type: Journal Article)
Chemical References
  • Gastrointestinal Hormones
Topics
  • Caloric Restriction
  • Diabetes Mellitus, Type 2 (surgery)
  • Gastric Bypass
  • Gastrointestinal Hormones
  • Humans
  • Insulin Resistance
  • Insulin-Secreting Cells

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