Metoclopramide for patients with intractable hiccups: a multicentre, randomised, controlled pilot study.

Abstract

BACKGROUND:

Limited data exist regarding the efficacy of metoclopramide in the treatment of intractable hiccups.

AIM:

This study aimed to assess the feasibility efficacy of metoclopramide in the treatment of patients with intractable hiccups.

METHODS:

A total of 36 patients with intractable hiccups was randomly assigned to arm A (n = 18) or arm B (n = 18) in a multicentre, double-blind, randomised, controlled pilot study. Participants in arm A received 10-mg metoclopramide thrice daily for 15 days, whereas those assigned to arm B received 10-mg placebo thrice daily for 15 days. The primary outcome measure was total efficacy against hiccups (including cessation and improvement of hiccups). Secondary outcome measures included a comparison of overall efficacy and adverse events between the two arms.

RESULTS:

Of the 36 patients enrolled, 34 participants completed the study. The total efficacy was higher in arm A than in arm B (relative risk, 2.75; 95% confidence interval: 1.09-6.94, P = 0.03). Furthermore, comparison between the two arms revealed that overall efficacy was higher in arm A than that in arm B (P < 0.05). No serious adverse events related to the treatment were documented in either arm. The most common adverse events occurring in patients in arm A included fatigue, upset mood and dizziness.

CONCLUSION:

Metoclopramide appears to be a promising candidate for the treatment of patients with intractable hiccups, with mild adverse events. However, further clinical trials are required to confirm these results.

• Authors: T Wang, D Wang
• Journal: Internal medicine journal (Intern Med J) Vol. 44 Issue 12a Pg. 1205-9 (Dec 2014) ISSN: 1445-5994 [Electronic] Australia
• PMID: 25069531 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 The Authors; Internal Medicine Journal © 2014 Royal Australasian College of Physicians.

Chemical References

• Dopamine D2 Receptor Antagonists
• Metoclopramide

Topics

• Adult
• Aged
• China
• Dopamine D2 Receptor Antagonists (administration & dosage, adverse effects, therapeutic use)
• Double-Blind Method
• Drug Administration Schedule
• Female
• Hiccup (drug therapy, physiopathology, prevention & control)
• Humans
• Male
• Metoclopramide (administration & dosage, adverse effects, therapeutic use)
• Middle Aged
• Pilot Projects
• Severity of Illness Index
• Treatment Outcome