Abstract | OBJECTIVES: DESIGN: Retrospective review. SETTING: Academic medical-surgical PICU. PATIENTS: INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Consent was obtained from 71 infants with complete DiGeorge anomaly for thymus transplantation, and 59 infants were transplanted. Median age at transplantation was 5.0 months (range, 1.1-22.1 mo). After transplantation, 12 of 59 infants (20%) required 25 emergent PICU admissions. Seven of 12 infants (58%) survived to PICU discharge with six surviving 6 months posttransplantation. Forty-two of 59 infants (71%) transplanted had congenital heart disease, and 9 of 12 (75%) who were admitted to the PICU had congenital heart disease. In 15 of 25 admissions (60%), intubation and mechanical ventilation were necessary. There was no difference between median ventilation-free days between infants with and without congenital heart disease (33 d vs 23 d, p = 0.544). There was also no correlation between ventilation-free days and age of transplantation (R, 0.17; p = 0.423). Age at transplantation and the presence of congenital heart disease were not associated with risk for PICU admission (odds ratio, 0.95; 95% CI, 0.78-1.15 and odds ratio, 1.27; 95% CI, 0.30-5.49, respectively) or PICU mortality (odds ratio, 0.98; 95% CI, 0.73-1.31 and odds ratio, 0.40; 95% CI, 0.15-1.07, respectively). CONCLUSIONS:
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Authors | Jan Hau Lee, M Louise Markert, Christoph P Hornik, Elizabeth A McCarthy, Stephanie E Gupton, Ira M Cheifetz, David A Turner |
Journal | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
(Pediatr Crit Care Med)
Vol. 15
Issue 7
Pg. e321-6
(Sep 2014)
ISSN: 1529-7535 [Print] United States |
PMID | 25068252
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Topics |
- Age Factors
- Critical Care
- DiGeorge Syndrome
(complications, mortality, surgery)
- Female
- Heart Defects, Congenital
(complications)
- Hospitalization
- Humans
- Infant
- Male
- Retrospective Studies
- Risk Factors
- Sepsis
(complications)
- Thymus Gland
(transplantation)
- Treatment Outcome
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