Abstract |
Current therapies for multiple sclerosis (MS) are largely palliative, not curative. Mesenchymal stem cells (MSCs) harbor regenerative and immunosuppressive functions, indicating a potential therapy for MS, yet the variability and low potency of MSCs from adult sources hinder their therapeutic potential. MSCs derived from human embryonic stem cells (hES-MSCs) may be better suited for clinical treatment of MS because of their unlimited and stable supply. Here, we show that hES-MSCs significantly reduce clinical symptoms and prevent neuronal demyelination in a mouse experimental autoimmune encephalitis (EAE) model of MS, and that the EAE disease-modifying effect of hES-MSCs is significantly greater than that of human bone-marrow-derived MSCs (BM-MSCs). Our evidence also suggests that increased IL-6 expression by BM-MSCs contributes to the reduced anti-EAE therapeutic activity of these cells. A distinct ability to extravasate and migrate into inflamed CNS tissues may also be associated with the robust therapeutic effects of hES-MSCs on EAE.
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Authors | Xiaofang Wang, Erin A Kimbrel, Kumiko Ijichi, Debayon Paul, Adam S Lazorchak, Jianlin Chu, Nicholas A Kouris, Gregory J Yavanian, Shi-Jiang Lu, Joel S Pachter, Stephen J Crocker, Robert Lanza, Ren-He Xu |
Journal | Stem cell reports
(Stem Cell Reports)
Vol. 3
Issue 1
Pg. 115-30
(Jul 08 2014)
ISSN: 2213-6711 [Print] United States |
PMID | 25068126
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Bone Marrow Cells
(cytology)
- Central Nervous System
(pathology)
- Disease Models, Animal
- Embryonic Stem Cells
(cytology)
- Encephalomyelitis, Autoimmune, Experimental
(therapy)
- Humans
- Mesenchymal Stem Cell Transplantation
- Mesenchymal Stem Cells
(cytology)
- Mice
- Multiple Sclerosis
(pathology, therapy)
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