Toxicokinetics and absolute oral bioavailability of melamine in broiler chickens.

Abstract

The objective of this study was to investigate the toxicokinetic characteristics of melamine in broilers due to the limited information available for livestock. Melamine was then administered to broiler chickens at an intravenous (i.v.) or oral (p.o.) dosage of 5.5 mg/kg of body weight, and plasma samples were collected up to 48 h. The concentration of melamine in each plasma sample was analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Melamine was measurable up to 24 h after i.v. and p.o. administration. A one-compartment model was developed to describe the toxicokinetics of melamine in broilers. Following i.v. administration, the values for the elimination half-life (t(1/2β)), the volume of distribution (Vd ), and the clearance (CL) were 4.42 ± 1.02 h, 00.52 ± 0.18 L/kg, and 0.08 ± 0.01 L/h/kg, respectively. The absolute oral bioavailability (F) was 95.63 ± 3.54%. The results suggest that most of the administered melamine is favorably absorbed from the alimentary tract and rapidly cleared by the kidneys in broiler chickens.

• Authors: S Poapolathep, N Klangkaew, P Arreesrisom, S Isariyodom, Y Sugita-Konishi, S Kumagai, A Poapolathep
• Journal: Journal of veterinary pharmacology and therapeutics (J Vet Pharmacol Ther) Vol. 38 Issue 1 Pg. 101-4 (Feb 2015) ISSN: 1365-2885 [Electronic] England
• PMID: 25066628 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 John Wiley & Sons Ltd.

Chemical References

• Triazines
• melamine

Topics

• Administration, Oral
• Animals
• Area Under Curve
• Biological Availability
• Chickens (blood)
• Half-Life
• Triazines (administration & dosage, blood, pharmacokinetics, toxicity)