Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice.

Abstract

Numerous studies have demonstrated that inflammation, oxidative stress and altered level of neurotrophins are involved in the pathogenesis of depressive illness. Mangiferin, a C-glucosylxanthone is abundant in the stem and bark of Mangifera indica L. The compound has been shown to possess antioxidant, anti-inflammatory and immunomodulatory activities. The present study was performed to investigate the effect of mangiferin pretreatment on lipopolysaccharide-induced increased proinflammatory cytokines, oxidative stress and neurobehavioural abnormalities. Mice were challenged with lipopolysaccharide (0.83 mg/kg, i.p.) after 14 days of mangiferin (20 and 40 mg/kg, p.o.) pretreatment. Mangiferin pretreatment significantly ameliorated the anxiety-like behaviour as evident from the results of an elevated plus maze, light-dark box and open field test. Mangiferin pretreatment also improved the anhedonic behaviour as revealed by sucrose preference test and increased social interaction time. It also prevented the lipopolysaccharide-evoked depressive-like effect by reducing the immobility time in forced swim and tail suspension test. Lipopolysaccharide-induced elevated oxidative stress was decreased with mangiferin pretreatment due to its potential to increase reduced glutathione concentration, Superoxide dismutase and catalase activity and decrease lipid peroxidation and nitrite level in the hippocampus as well as in the prefrontal cortex. Mangiferin pretreatment also attenuated neuroinflammation by reducing the interleukin-1 beta (IL-1β) level in hippocampus and prefrontal cortex. In conclusion, our results demonstrated that mangiferin possessed antidepressant and anti-anxiety properties due to its ability to attenuate IL-1β level and oxidative stress evoked by intraperitoneal administration of lipopolysaccharide. Mangiferin may be a potential therapeutic agent for the treatment of depressive and anxiety illness.

• Authors: Ashok Jangra, Manish M Lukhi, Kunjbihari Sulakhiya, Chandana C Baruah, Mangala Lahkar
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 740 Pg. 337-45 (Oct 05 2014) ISSN: 1879-0712 [Electronic] Netherlands
• PMID: 25064341 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014. Published by Elsevier B.V.

Chemical References

• Anti-Anxiety Agents
• Antidepressive Agents
• Antioxidants
• Brain-Derived Neurotrophic Factor
• Interleukin-1beta
• Lipopolysaccharides
• Nitrites
• Thiobarbituric Acid Reactive Substances
• Tumor Necrosis Factor-alpha
• Xanthones
• mangiferin
• Malondialdehyde
• Catalase
• Superoxide Dismutase
• Glutathione

Topics

• Animals
• Anti-Anxiety Agents (pharmacology, therapeutic use)
• Antidepressive Agents (pharmacology, therapeutic use)
• Antioxidants (pharmacology, therapeutic use)
• Anxiety (prevention & control)
• Behavior, Animal (drug effects)
• Brain-Derived Neurotrophic Factor (metabolism)
• Catalase (metabolism)
• Depression (prevention & control)
• Glutathione (metabolism)
• Hippocampus (drug effects, metabolism)
• Interleukin-1beta (metabolism)
• Lipopolysaccharides
• Male
• Malondialdehyde (metabolism)
• Mice
• Nitrites (metabolism)
• Oxidative Stress (drug effects)
• Prefrontal Cortex (drug effects, metabolism)
• Superoxide Dismutase (metabolism)
• Thiobarbituric Acid Reactive Substances (metabolism)
• Tumor Necrosis Factor-alpha (metabolism)
• Xanthones (pharmacology, therapeutic use)