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Photoperiod influences the growth of colon cancer in mice.

Abstract
We have developed a mouse colon adenocarcinoma cell line that produces tumors in a dose-dependent manner when injected subcutaneously. Our previous work has demonstrated its sequential pattern of tumor area and weight under 12L:12D (12 hours light, 12 hours darkness) photoperiod. This study investigated whether shorter (6L:18D) or longer (18L:6D) photoperiods alter tumor growth. Significantly greater tumor area, weight, and group mortality were found in mice exposed to 12L:12D photoperiods as compared to either 6L:18D or 18L:6D photoperiods, and difluoromethylornithine (DFMO) was a more effective inhibitor of tumor growth under the 6L:18D photoperiod compared to 12L:12D. These results demonstrate an important role of photoperiod on tumor growth.
AuthorsR D Waldrop, R Saydjari, N H Rubin, P L Rayford, C M Townsend Jr, J C Thompson
JournalLife sciences (Life Sci) Vol. 45 Issue 8 Pg. 737-44 ( 1989) ISSN: 0024-3205 [Print] Netherlands
PMID2506401 (Publication Type: Journal Article)
Chemical References
  • Eflornithine
Topics
  • Adenocarcinoma (drug therapy, pathology)
  • Animals
  • Body Weight
  • Circadian Rhythm
  • Colonic Neoplasms (drug therapy, pathology)
  • Eflornithine (therapeutic use)
  • Light
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Organ Size
  • Random Allocation
  • Spleen (pathology)
  • Testis (pathology)
  • Tumor Cells, Cultured

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