Abstract |
We have developed a mouse colon adenocarcinoma cell line that produces tumors in a dose-dependent manner when injected subcutaneously. Our previous work has demonstrated its sequential pattern of tumor area and weight under 12L:12D (12 hours light, 12 hours darkness) photoperiod. This study investigated whether shorter (6L:18D) or longer (18L:6D) photoperiods alter tumor growth. Significantly greater tumor area, weight, and group mortality were found in mice exposed to 12L:12D photoperiods as compared to either 6L:18D or 18L:6D photoperiods, and difluoromethylornithine (DFMO) was a more effective inhibitor of tumor growth under the 6L:18D photoperiod compared to 12L:12D. These results demonstrate an important role of photoperiod on tumor growth.
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Authors | R D Waldrop, R Saydjari, N H Rubin, P L Rayford, C M Townsend Jr, J C Thompson |
Journal | Life sciences
(Life Sci)
Vol. 45
Issue 8
Pg. 737-44
( 1989)
ISSN: 0024-3205 [Print] Netherlands |
PMID | 2506401
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adenocarcinoma
(drug therapy, pathology)
- Animals
- Body Weight
- Circadian Rhythm
- Colonic Neoplasms
(drug therapy, pathology)
- Eflornithine
(therapeutic use)
- Light
- Male
- Mice
- Mice, Inbred BALB C
- Organ Size
- Random Allocation
- Spleen
(pathology)
- Testis
(pathology)
- Tumor Cells, Cultured
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