Abstract | OBJECTIVES: To examine the prevalence of multidrug-resistant (MDR) urinary Escherichia coli among US outpatients and to assess the antimicrobial activity of oral antibiotics commonly used to treat urinary tract infections (UTIs) against MDR isolates. METHODS: RESULTS: Prevalence of MDR E. coli increased from 9.1% in 2001 (n = 29,198) to 17.0% in 2010 (n = 32,742) (P < 0.0001). In isolates that demonstrated resistance to three, four or five antimicrobial agents in 2010, resistance to nitrofurantoin was observed in only 2.1%, 7.5% and 24.1% of isolates, respectively. Conversely, widespread resistance was observed for trimethoprim/sulfamethoxazole (62.6%, 88.6% and 97.9% for isolates resistant to three, four and five agents, respectively) and ciprofloxacin (48.9%, 84.3% and 98.2% for isolates resistant to three, four and five agents, respectively). CONCLUSIONS: Because of its consistent antimicrobial activity against MDR E. coli, nitrofurantoin remains a reliable first-line agent for the empirical treatment of acute uncomplicated cystitis.
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Authors | G V Sanchez, A M G Baird, J A Karlowsky, R N Master, J M Bordon |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 69
Issue 12
Pg. 3259-62
(Dec 2014)
ISSN: 1460-2091 [Electronic] England |
PMID | 25063776
(Publication Type: Journal Article)
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Copyright | © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: [email protected]. |
Chemical References |
- Anti-Bacterial Agents
- Nitrofurantoin
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Topics |
- Anti-Bacterial Agents
(pharmacology)
- Drug Resistance, Multiple, Bacterial
- Escherichia coli
(drug effects, isolation & purification)
- Escherichia coli Infections
(microbiology)
- Humans
- Microbial Sensitivity Tests
- Nitrofurantoin
(pharmacology)
- Outpatients
- United States
- Urinary Tract Infections
(microbiology)
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