Abstract | BACKGROUND: METHODS: Seventy-five FMF patients who have no exclusion criteria and healthy controls (n = 36) were included. Serum galectin-3 was measured and morning spot urine was collected for determination of the protein/ creatinine ratio (PCR). RESULTS: Serum Galectin-3 levels were significantly higher in FMF patients than the control group [969.66 (3825) pg/mL vs. 238 (921) pg/mL, respectively; P<0.001]. We classified into two groups: Group1 (n = 48) had FMF patients with proteniuria, Group2 (n = 27) had FMF patients without proteinuria. Group1 had higher levels of galectin-3 than Group2 [1106(3812) pg/mL vs. 867.3(1433) pg/mL, P < 0.001]. Galectin-3 levels were correlated with PCR in whole group and FMF group (r = 0.785, P < 0.001 and r = 0.803, P < 0.001). In ROC curve, best cutoff value = 581.50 pg/mL was used to detect proteinuria (sensitivity = 91.7 %, specificity = 71.4 %, AUC = 0.879) and optimal cutoff value = 1458.00 pg/mL was an indicator of nephrotic-range proteinuric (sensitivity = 100 %, specificity = 92.1 %, AUC = 0.983). CONCLUSION:
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Authors | Hakki Yilmaz, Osman Inan, Tahir Darcin, Mukadder Ayse Bilgic, Ali Akcay |
Journal | Clinical and experimental nephrology
(Clin Exp Nephrol)
Vol. 19
Issue 3
Pg. 436-42
(Jun 2015)
ISSN: 1437-7799 [Electronic] Japan |
PMID | 25059227
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Amyloidosis
(blood, etiology, urine)
- Area Under Curve
- Case-Control Studies
- Familial Mediterranean Fever
(blood, complications)
- Female
- Galectin 3
(blood)
- Humans
- Kidney Diseases
(blood, etiology, urine)
- Male
- Proteinuria
(blood)
- ROC Curve
- Young Adult
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