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Annexin A11 (ANXA11) gene polymorphisms are associated with sarcoidosis in a Han Chinese population: a case-control study.

AbstractOBJECTIVES:
To further identify the single-nucleotide polymorphisms (SNPs) that contribute to the genetic susceptibility to sarcoidosis, we examined the potential association between sarcoidosis and 15 SNPs of the ANXA11 gene.
DESIGN:
A case-control study.
SETTING:
A tuberculosis unit in a hospital of the university in China.
PARTICIPANTS:
Participants included 412 patients with sarcoidosis and 418 healthy controls.
METHODS:
The selected SNPs were genotyped using the MALDI-TOF in the MassARRAY system.
RESULTS:
Statistically significant differences were found in the allelic or genotypic frequencies of the rs2789679, rs1049550 and rs2819941 in the ANXA11 gene between patients with sarcoidosis and controls. The rs2789679 A allele (p=0.00004, OR=1.42, 95% CI 1.17 to 1.73) and rs2819941 T allele (p=0.0006, OR=1.41, 95% CI 1.16 to 1.71) were significantly more frequent in patients with sarcoidosis compared with controls. The frequency of the rs1049550 T allele (p=0.000002, OR=0.61, 95% CI 0.49 to 0.74) in patients with sarcoidosis was significantly lower than that in controls. The multi-SNP model reveals that rs1049550 is the only independent SNP association effect after accounting for the other two marginally associated SNPs. In block 2 (rs1049550-rs2573351), the T-C haplotype occurred significantly less frequently (p=0.001), whereas the C-C haplotypes occurred more frequently (p=0.0001) in patients with sarcoidosis than controls. Furthermore, genotype frequency distribution revealed that, in rs1049550, the CC genotype was significantly more in patients with chest X-ray (CXR) stage I sarcoidosis than in patients with CXR stage II-IV sarcoidosis (p=0.012).
CONCLUSIONS:
These findings point to a role for the polymorphisms of ANXA11 in sarcoidosis in a Chinese Han population, and may be informative for future genetic studies on sarcoidosis.
AuthorsXianjun Feng, Shuzhi Zang, Yanrong Yang, Shasha Zhao, Yunxia Li, Xinyuan Gao, Ligong Zhang
JournalBMJ open (BMJ Open) Vol. 4 Issue 7 Pg. e004466 (Jul 23 2014) ISSN: 2044-6055 [Print] England
PMID25056970 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightPublished by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Chemical References
  • Annexins
  • DNA
Topics
  • Alleles
  • Annexins (genetics, metabolism)
  • China (epidemiology)
  • DNA (genetics)
  • Ethnicity
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Prevalence
  • Retrospective Studies
  • Sarcoidosis (ethnology, genetics, metabolism)

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