Influence of anthropometric measurements on abnormal gonadotropin secretion in women with polycystic ovary syndrome.

Abstract

OBJECTIVE:

To evaluate the influence of anthropometric measurements on abnormal gonadotropin secretion in patients with polycystic ovary syndrome (PCOS).

STUDY DESIGN:

Cross-sectional study.

PLACE AND DURATION OF STUDY:

The Institute of Basic Medical Sciences (IBMS), DUHS in collaboration with Gynae/infertility clinics of the Civil Hospital and Lady Dufferin Hospital, Karachi, from October 2010 to February 2011.

METHODOLOGY:

One hundred and sixty three oligomenorrhic PCOS women of reproductive age (18 - 40 years) fulfilling the revised Rotterdam 2003 criteria were studied. The data recorded on a prescribed proforma included current age, age at menarche, menstrual irregularities, presence of hirsuitism, acne, infertility, familial nature, blood pressure, BMI and waist-hip ratio. Blood samples for gonadotropin assay were taken randomly on day 6th to 30th of menstrual cycle, in a gel tube. Hormonal assay was performed using chemiluminescent immunoassay. Kruskul Wallis test was used to assess the influence of BMI levels on LH:FSH values.

RESULTS:

The mean weight was 66.14 ± 11.02 kg and mean BMI was 27.03 ± 4.42 kg/m2. There was no significant difference in mean LH/FSH ratio (p=.575) among BMI groups. However, there was a positive correlation between BMI and LH:FSH ratio (p=0.04, r=0.155).

CONCLUSION:

There was high frequency of obesity (69%) in women with PCOS. Although no significant difference was found between mean LH:FSH ratio among different BMI groups levels but significant correlation between BMI levels and LH: FSH suggested that there was positive relation between BMI and LH: FSH.

• Authors: Shehla Haider, Nighat Mannan, Ayesha Khan, Masood A Qureshi
• Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP (J Coll Physicians Surg Pak) Vol. 24 Issue 7 Pg. 463-6 (Jul 2014) ISSN: 1681-7168 [Electronic] Pakistan
• PMID: 25052966 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gonadotropins
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Adolescent
• Adult
• Body Mass Index
• Cross-Sectional Studies
• Female
• Follicle Stimulating Hormone (blood)
• Gonadotropins (blood)
• Humans
• Luminescent Measurements
• Luteinizing Hormone (blood)
• Pakistan
• Polycystic Ovary Syndrome (blood)
• Statistics, Nonparametric
• Waist-Hip Ratio
• Young Adult