Abstract | OBJECTIVE: To evaluate the effect of Jatropha seed oils extracted by different methods on killing cercaria of Schistosomajaponicum so as to screen the optimum process and formulations. METHODS: The cercaria directly contacting tests with Jatropha seed oils extracted by 6 different extraction processes were carried out, and the mouse immediate contacting cercaria infection trials with different formulations of Jatropha seed oil and various additives were performed. RESULTS: With 95% ethanol, the ratio of material to liquid being 1:8, and 2 h extraction, the oil extraction rate was 30.7%. The cercaria directly contacting tests showed that 6 kinds of Jatropha seed oil killed all cercaria within 30 min. In the mouse immediate contacting cercaria infection trials, the worm declined rate of Jatropha seed oil liquid was 70.97%, and the worm declined rate of the sample added with benzyl benzoate was 58.87%, and the worm declined rate of the sample added with laurocapram was 77.42%. The worm declined rate of the samples added with benzyl benzoate, dibutyl phthalate and laurocapram was 100%. CONCLUSION: The process with 95% ethanol, the ratio of material to liquid being 1:8, and 2 h extraction is the optimum, and the Jatropha seed oil has a good killing schistosome cercaria effect.
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Authors | Ping Yi, Qu-zhi Yu, Wen Qu, Ying Xia, Wen-hua Cheng, Shuang Li, Qin-qi Liu, Yao Tong, Li-jun Tang |
Journal | Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control
(Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi)
Vol. 26
Issue 2
Pg. 187-8, 191
(Apr 2014)
ISSN: 1005-6661 [Print] China |
PMID | 25051835
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Animals
- Cercaria
(drug effects)
- Chemical Fractionation
(methods)
- Female
- Jatropha
(chemistry)
- Male
- Mice
- Plant Oils
(isolation & purification, pharmacology)
- Schistosoma japonicum
(drug effects)
- Seeds
(chemistry)
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