Ventricular tachycardia-flutter associated with disopyramide therapy: a report of three cases.

Abstract

Three patients developed episodes of ventricular tachycardia and/or flutter-fibrillation while receiving disopyramide (Norpace). Syncope was the presenting complaint in all of them. The arrhythmias did not recur after disopyramide was discontinued. The Q-T interval was markedly prolonged in all three patients. One patient developed syncope associated with both quinidine and Norpace therapy. It is postulated that disopyramide, like quinidine, may provoke ventricular flutter-fibrillation in sensitive patients by similar mechanisms.

• Authors: R W Dhurandhar, K Nademanee, A M Goldman
• Journal: Heart & lung : the journal of critical care (Heart Lung) 1978 Sep-Oct Vol. 7 Issue 5 Pg. 783-7 ISSN: 0147-9563 [Print] United States
• PMID: 250503 (Publication Type: Case Reports, Journal Article)

Chemical References

• Pyridines
• Disopyramide
• Quinidine

Topics

• Aged
• Arrhythmias, Cardiac (drug therapy)
• Disopyramide (adverse effects)
• Electrocardiography
• Female
• Humans
• Middle Aged
• Pyridines (adverse effects)
• Quinidine (adverse effects)
• Syncope (chemically induced)
• Tachycardia (chemically induced)