Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat province, Western Cambodia.

Abstract

Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported. The use of artemisinin (ART)-based combination therapies (ACTs) to treat CQ-sensitive P. vivax infections is effective and convenient but may promote the emergence and worsening of ART resistance in sympatric Plasmodium falciparum populations. Here, we show that CQ effectively treats P. vivax malaria in Pursat Province, western Cambodia, where ART-resistant P. falciparum is highly prevalent and spreading. (This study has been registered at ClinicalTrials.gov under registration no. NCT00663546.).

• Authors: Chanaki Amaratunga, Sokunthea Sreng, Sivanna Mao, Gregory S Tullo, Jennifer M Anderson, Char Meng Chuor, Seila Suon, Rick M Fairhurst
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 58 Issue 10 Pg. 6270-2 (Oct 2014) ISSN: 1098-6596 [Electronic] United States
• PMID: 25049249 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Chemical References

• Anti-Infective Agents
• Artemisinins
• Chloroquine
• artemisinin

Topics

• Anti-Infective Agents (pharmacology)
• Artemisinins (pharmacology)
• Cambodia
• Chloroquine (pharmacology)
• Drug Resistance
• Malaria
• Plasmodium vivax (drug effects)