Cytochrome P450 1A1 (CYP1A1) polymorphism and susceptibility to esophageal cancer: an updated meta-analysis of 27 studies.

Abstract

Cytochrome P450 1A1 (CYP1A1) polymorphisms are known to play a crucial role in the development and metastasis of malignant diseases including esophageal cancer. However, the results of previous studies investigating the association between CYP1A1 polymorphisms and esophageal cancer risk have been inconsistent. This meta-analysis of 27 eligible studies, encompassing 4,215 esophageal cancer cases and 6,339 control subjects, pooled the odds ratios (ORs) with corresponding 95 % confidence intervals (95 % CI) to assess this association. The effects of ethnicity (Caucasian and Asian) and histopathology type (esophageal squamous cell carcinoma and esophageal adenocarcinoma) were considered in subgroup analyses. A significant association was observed between the CYP1A1 Ile/Val gene polymorphism and esophageal cancer in all of the genetic models (Ile/Val vs. Ile/Ile, OR = 1.41, 95 % CI = 1.25-1.58; Val/Val vs. Ile/Ile, OR = 1.94, 95 % CI = 1.34-2.82; Ile/Val + Val/Val vs. Ile/Ile, OR = 1.49, 95 % CI = 1.33-1.66). The subgroup analysis based on ethnicity showed that the association between the CYP1A1 Ile/Val polymorphism and esophageal cancer existed in Asian and Caucasian populations. However, no association was observed between the CYP1A1 MspI polymorphism and esophageal cancer in either subgroup or in the overall population. These results suggested that the CYP1A1 Ile/Val polymorphism was associated with an increased risk of esophageal cancer, whereas the CYP1A1 MspI polymorphism may not have increased susceptibility to esophageal cancer. Further studies are required to confirm these findings.

• Authors: Feng-Feng Gong, Shan-Shan Lu, Cai-Yun Hu, Zhen-Zhong Qian, Fang Feng, Yi-Le Wu, Hui-Yun Yang, Ye-Huan Sun
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 10 Pg. 10351-61 (Oct 2014) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 25048966 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• CYP1A1 protein, human
• Cytochrome P-450 CYP1A1

Topics

• Adenocarcinoma (enzymology, genetics)
• Carcinoma, Squamous Cell (enzymology, genetics)
• Cytochrome P-450 CYP1A1 (genetics)
• Esophageal Neoplasms (enzymology, genetics)
• Esophageal Squamous Cell Carcinoma
• Genetic Predisposition to Disease (genetics)
• Humans
• Polymorphism, Single Nucleotide (genetics)