Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: At 4 weeks after treatment lipo- botulinum toxin instillation was associated with a statistically significant decrease in micturition events per 3 days (-4.64 for lipo- botulinum toxin vs -0.19 for placebo, p = 0.0252). Lipo- botulinum toxin instillation was also associated with a statistically significant decrease in urinary urgency events with respect to baseline but not placebo. However, lipo- botulinum toxin instillation was associated with a statistically significant decrease in urgency severity scores compared to placebo (p = 0.0181). These observed benefits of lipo- botulinum toxin instillation were not accompanied by an increased risk of urinary retention. The effects of lipo- botulinum toxin on urinary urge incontinence were inconclusive. CONCLUSIONS:
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Authors | Yao-Chi Chuang, Jonathan H Kaufmann, David D Chancellor, Michael B Chancellor, Hann-Chorng Kuo |
Journal | The Journal of urology
(J Urol)
Vol. 192
Issue 6
Pg. 1743-9
(Dec 2014)
ISSN: 1527-3792 [Electronic] United States |
PMID | 25046622
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Acetylcholine Release Inhibitors
- Liposomes
- Botulinum Toxins, Type A
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Topics |
- Acetylcholine Release Inhibitors
(administration & dosage)
- Administration, Intravesical
- Aged
- Botulinum Toxins, Type A
(administration & dosage)
- Double-Blind Method
- Female
- Humans
- Liposomes
- Male
- Middle Aged
- Prospective Studies
- Remission Induction
- Urinary Bladder, Overactive
(drug therapy)
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