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Accelerating bleaching in vitiligo: balancing benefits versus risks.

Abstract
While the goal of available treatment in vitiligo is to regain pigmentation, some patients affected by extensive and treatment-resistant vitiligo, with a major social and emotional impact, may benefit from depigmentation therapy. However, results from such therapy may not always be satisfactory. So to achieve better, faster and complete bleaching, Webb et al. propose a synergistic approach that combines topical application of bleaching phenols which targets melanocytes and initiate local inflammation with immune adjuvants so as to obtain an enhanced immune response against remaining melanocytes. This strategy could be reliable, but should be evaluated cautiously in future studies, in terms of potential side effects and induction of undesired autoimmunity.
AuthorsJulien Seneschal, Katia Boniface, Khaled Ezzedine, Alain Taieb
JournalExperimental dermatology (Exp Dermatol) Vol. 23 Issue 12 Pg. 879-80 (Dec 2014) ISSN: 1600-0625 [Electronic] Denmark
PMID25039467 (Publication Type: Journal Article, Review)
Copyright© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Chemical References
  • Adjuvants, Immunologic
  • Aminoquinolines
  • Hydroquinones
  • Skin Lightening Preparations
  • monobenzone
  • Imiquimod
Topics
  • Adjuvants, Immunologic (administration & dosage, adverse effects)
  • Administration, Topical
  • Aminoquinolines (administration & dosage, adverse effects)
  • Humans
  • Hydroquinones (administration & dosage, adverse effects)
  • Imiquimod
  • Melanocytes (drug effects, immunology, pathology)
  • Risk Assessment
  • Skin Lightening Preparations (administration & dosage, adverse effects)
  • Vitiligo (immunology, pathology, therapy)

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