FOLFIRINOX for locally advanced pancreatic adenocarcinoma: results of an AGEO multicenter prospective observational cohort.

Abstract

BACKGROUND:

First-line treatment with FOLFIRINOX significantly increases overall survival (OS) in patients with metastatic pancreatic adenocarcinoma (PA) compared with gemcitabine. The aim of this observational cohort was to evaluate the tolerability and efficacy of this regimen in unresectable locally advanced PA (LAPA).

PATIENTS AND METHODS:

From February 2010 to February 2012, all consecutive patients from 11 French centers treated by FOLFIRINOX for a histologically proven LAPA were prospectively enrolled. Unresectability was defined independently by each center's multidisciplinary staff at diagnosis. Absence of metastatic disease was confirmed by chest-abdomen-pelvis computed tomography scan. FOLFIRINOX was delivered every 2 weeks as previously reported until progressive disease, major toxicity, or consolidation treatment by radiotherapy and/or surgery.

RESULTS:

Seventy-seven patients were enrolled. They received a median number of five cycles (1-30). Grade 3-4 toxicities were neutropenia (11 %), nausea (9 %), diarrhea (6 %), fatigue (6 %), and anemia (1 %). Grade 2-3 sensory neuropathy occurred in 25 % of patients. No toxic death was reported and only 6 % of patients had to stop treatment because of toxicity. Disease control rate was 84 with 28 % of objective response (Response Evaluation Criteria in Solid Tumors). Seventy-five percent of patients received a consolidation therapy: 70 % had radiotherapy and 36 % underwent a surgical resection, with a curative intent. Within the whole cohort, 1-year OS rate was 77 % (95 % CI 65-86) and 1-year progression-free survival rate was 59 % (95 % CI 46-70).

CONCLUSION:

First-line FOLFIRINOX for LAPA seems to be effective and have a manageable toxicity profile. These promising results will have to be confirmed in a phase III randomized trial.

• Authors: L Marthey, A Sa-Cunha, J F Blanc, M Gauthier, A Cueff, E Francois, I Trouilloud, D Malka, J B Bachet, R Coriat, E Terrebonne, C De La Fouchardière, S Manfredi, D Solub, C Lécaille, A Thirot Bidault, F Carbonnel, J Taieb
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 22 Issue 1 Pg. 295-301 (Jan 2015) ISSN: 1534-4681 [Electronic] United States
• PMID: 25037971 (Publication Type: Journal Article, Multicenter Study, Observational Study)

Chemical References

• Deoxycytidine
• Irinotecan
• Cisplatin
• Leucovorin
• Fluorouracil
• Camptothecin
• Gemcitabine

Topics

• Adenocarcinoma (drug therapy, mortality, pathology)
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives)
• Cisplatin (administration & dosage)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Female
• Fluorouracil (administration & dosage)
• Follow-Up Studies
• Humans
• Irinotecan
• Leucovorin (administration & dosage)
• Male
• Maximum Tolerated Dose
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local (drug therapy, mortality, pathology)
• Neoplasm Staging
• Pancreatic Neoplasms (drug therapy, mortality, pathology)
• Prognosis
• Prospective Studies
• Survival Rate
• Gemcitabine