In the present study, the intention was to reveal the relationship of histological grade and stage with c-erbB2, CD44s, and
PCNA immunoreactivity in bladder urothelial
carcinomas (UC). In our study, we evaluated 46 items of transurethral resection material of patients submitted by YYU Faculty of Medicine, Main Department of Pathology, with a mass revealed in their bladder after clinical and radiological studies at our laboratories and who were diagnosed with urothelial
carcinomas.
PCNA, c-erbB2, and CD44s were applied in an immunohistochemical manner comprised from nine low-malignant potential papillary urothelial
neoplasia, 23 low-grade papillary urothelial
carcinoma, and 14 high-grade papillary urothelial
carcinoma. Immunostaining was scored according to the percentage of positive cells. The immunohistochemical study demonstrated that the c-erbB2 and
PCNA staining ratio increased when an increase occurred in stage and grade. The CD44s staining ratio decreased. C-erbB2,
PCNA, and CD44s appear to be a useful marker in the assessment of the prognosis and treatment options in urothelial
carcinomas.