Tissue oxygen saturation during hyperthermic progressive central hypovolemia.

Abstract

During normothermia, a reduction in near-infrared spectroscopy (NIRS)-derived tissue oxygen saturation (So2) is an indicator of central hypovolemia. Hyperthermia increases skin blood flow and reduces tolerance to central hypovolemia, both of which may alter the interpretation of tissue So2 during central hypovolemia. This study tested the hypothesis that maximal reductions in tissue So2 would be similar throughout normothermic and hyperthermic central hypovolemia to presyncope. Ten healthy males (means ± SD; 32 ± 5 yr) underwent central hypovolemia via progressive lower-body negative pressure (LBNP) to presyncope during normothermia (skin temperature ≈34°C) and hyperthermia (+1.2 ± 0.1°C increase in internal temperature via a water-perfused suit, skin temperature ≈39°C). NIRS-derived forearm (flexor digitorum profundus) tissue So2 was measured throughout and analyzed as the absolute change from pre-LBNP. Hyperthermia reduced (P < 0.001) LBNP tolerance by 49 ± 33% (from 16.7 ± 7.9 to 7.2 ± 3.9 min). Pre-LBNP, tissue So2 was similar (P = 0.654) between normothermia (74 ± 5%) and hyperthermia (73 ± 7%). Tissue So2 decreased (P < 0.001) throughout LBNP, but the reduction from pre-LBNP to presyncope was greater during normothermia (-10 ± 6%) than during hyperthermia (-6 ± 5%; P = 0.041). Contrary to our hypothesis, these findings indicate that hyperthermia is associated with a smaller maximal reduction in tissue So2 during central hypovolemia to presyncope.

• Authors: Zachary J Schlader, Eric Rivas, Babs R Soller, Victor A Convertino, Craig G Crandall
• Journal: American journal of physiology. Regulatory, integrative and comparative physiology (Am J Physiol Regul Integr Comp Physiol) Vol. 307 Issue 6 Pg. R731-6 (Sep 15 2014) ISSN: 1522-1490 [Electronic] United States
• PMID: 25031230 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Oxygen

Topics

• Adult
• Arterial Pressure
• Fever (metabolism, physiopathology)
• Forearm
• Heart Rate
• Humans
• Hypovolemia (metabolism, physiopathology)
• Lower Body Negative Pressure
• Male
• Muscle, Skeletal (metabolism)
• Oxygen (metabolism)
• Oxygen Consumption
• Regional Blood Flow
• Skin (blood supply)
• Skin Temperature
• Spectroscopy, Near-Infrared
• Syncope (metabolism, physiopathology)
• Time Factors