Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit.

Abstract

BACKGROUND:

The aim of this study was to evaluate prognostic factors including efficacy of postoperative chemotherapy in Japanese patients with uterine carcinosarcoma.

METHODS:

We conducted a retrospective survey of seven medical facilities in the Tohoku Gynecologic Cancer Unit.

RESULTS:

A total of 45 patients who had undergone hysterectomy and bilateral salpingo-oophorectomy were enrolled. No significant difference was observed in overall survival according to patient age (≤ 50 years vs >50 years) or retroperitoneal lymphadenectomy (performed vs. not performed). However, the International Federation of Gynecology and Obstetrics stage (stage I/II vs stage III/IV) and postoperative chemotherapy (provided vs not provided) were significant prognostic factors in both univariate and multivariate analyses for the 25-month median follow-up period.

CONCLUSIONS:

Our results revealed that postoperative chemotherapy should be considered for all uterine carcinosarcoma stages in Japanese patients.

• Authors: Ai Otsuki, Takeo Otsuki, Hideki Tokunaga, Hitoshi Niikura, Satoru Nagase, Takashi Sugiyama, Masafumi Toyoshima, Hiroki Utsunomiya, Yoshihito Yokoyama, Hideki Mizunuma, Naoki Sato, Yukihiro Terada, Tadahiro Shoji, Toru Sugiyama, Kenji Nakahara, Tsuyoshi Ohta, Hidekazu Yamada, Toru Tase, Hiroshi Nishiyama, Keiya Fujimori, Tadao Takano, Fumiaki Takahashi, Yoh Watanabe, Nobuo Yaegashi
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 20 Issue 3 Pg. 574-8 (Jun 2015) ISSN: 1437-7772 [Electronic] Japan
• PMID: 25030547 (Publication Type: Journal Article, Multicenter Study)

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinosarcoma (drug therapy, surgery)
• Chemotherapy, Adjuvant
• Female
• Humans
• Middle Aged
• Prognosis
• Retrospective Studies
• Survival Analysis
• Uterine Neoplasms (drug therapy, surgery)