Central nervous system manifestations of a valproic acid overdose responsive to naloxone.

Abstract

We report the case of a 22-year-old man who presented with a depressed level of consciousness after ingesting valproic acid. He responded to IV naloxone; over a nine-hour period, his serum valproic acid level decreased from 180.4 to 59.2 micrograms/ml with multiple-dose charcoal therapy. We recommend the use of both agents in the treatment of valproic acid overdose.

• Authors: G Alberto, T Erickson, R Popiel, M Narayanan, D Hryhorczuk
• Journal: Annals of emergency medicine (Ann Emerg Med) Vol. 18 Issue 8 Pg. 889-91 (Aug 1989) ISSN: 0196-0644 [Print] United States
• PMID: 2502939 (Publication Type: Case Reports, Journal Article)

Chemical References

• Charcoal
• Naloxone
• Sorbitol
• Valproic Acid

Topics

• Adult
• Brain (drug effects)
• Charcoal (therapeutic use)
• Consciousness (drug effects)
• Humans
• Male
• Naloxone (administration & dosage, therapeutic use)
• Sorbitol (therapeutic use)
• Valproic Acid (antagonists & inhibitors, blood, poisoning)