Abstract | BACKGROUND: The aim of this investigation is to study the relationship between gastric morphology and serum biomarkers before and after Helicobacter pylori eradication. METHODS: First-degree relatives of gastric cancer patients underwent gastroscopy before and 2.5 years after H. pylori eradication. The morphological changes in two categories (normal to mild and moderate to severe) were compared with level of pepsinogens I and II before eradication (n = 369), after eradication (n = 115), and in those with persistent infection (n = 250). RESULTS: CONCLUSION:
Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication.
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Authors | Sadegh Massarrat, Arghavan Haj-Sheykholeslami, Ashraf Mohamadkhani, Nasrin Zendehdel, Ali Aliasgari, Naser Rakhshani, Manfred Stolte, Seyed Mehdi Shahidi |
Journal | BioMed research international
(Biomed Res Int)
Vol. 2014
Pg. 481607
( 2014)
ISSN: 2314-6141 [Electronic] United States |
PMID | 25028655
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Biomarkers, Tumor
- Pepsinogen C
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(blood)
- Double-Blind Method
- Female
- Helicobacter Infections
(blood, therapy)
- Helicobacter pylori
- Humans
- Male
- Middle Aged
- Pepsinogen C
(blood)
- Stomach Neoplasms
(blood, surgery)
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