Late-onset subcutaneous scalp calcifications in a patient with pseudo-pseudohypoparathyroidism.

Abstract

Ectopic calcifications and even bone formation have been linked to GNAS gene mutations. A 51-year-old Caucasian female had been diagnosed of pseudo-pseudohypoparathyroidism (PPHP) in 1989. She has always had normal serum parathyroid hormone, calcium, and phosphorus levels. A non-contrast computed tomography of the head was done in 2013 and it showed finely speckled subcutaneous calcifications in the high convexity of the head. Cutaneous exploration did not show any abnormality. We herein report an unusual case of late-onset scalp calcifications in a patient with PPHP.

• Authors: Laura Ramos, María Piedra, Elena Sánchez, José A Amado
• Journal: Calcified tissue international (Calcif Tissue Int) Vol. 95 Issue 3 Pg. 292-4 (Sep 2014) ISSN: 1432-0827 [Electronic] United States
• PMID: 25027856 (Publication Type: Case Reports, Journal Article)

Chemical References

• Chromogranins
• GNAS protein, human
• GTP-Binding Protein alpha Subunits, Gs

Topics

• Age of Onset
• Calcinosis (etiology, pathology)
• Chromogranins
• Female
• Frameshift Mutation
• GTP-Binding Protein alpha Subunits, Gs (genetics)
• Humans
• Middle Aged
• Pseudopseudohypoparathyroidism (complications, genetics, pathology)
• Scalp (pathology)