Low vaccine efficacy of mumps component among MMR vaccine recipients in Chennai, India.

Abstract

Introduction of MMR vaccine was believed to have resulted in a decline in the incidence of measles, mumps and rubella infections. However, recent reports suggest the re-emergence of mumps infection worldwide in the vaccinated populations. It was proposed that the reason for this re-emergence was poor efficacy of MMR vaccine. The present study was aimed to investigate mumps infection in MMR vaccinated and non-vaccinated populations in Chennai, India. Blood samples were collected from acute mumps cases (n=74, 42<12 yr age, 54% males) and investigated for IgM antibody against mumps, IgG antibody against measles, mumps and rubella viruses by ELISA. Sixty seven (91%) patients had received MMR vaccine. All the 67 vaccinated cases were positive for parotitis, and mumps IgM. However, only 10 (15%) were positive for IgG. All samples (100%) were positive for rubella and measles IgG. These findings showed the occurrence of mumps infection among MMR vaccinated individuals in Chennai, India. The MMR vaccine failed to generate anti-mumps IgG. The reason may be low vaccine efficacy of the mumps component of the MMR vaccine used.

• Authors: Jeevan Malaiyan, Thangam Menon
• Journal: The Indian journal of medical research (Indian J Med Res) Vol. 139 Issue 5 Pg. 773-5 (May 2014) ISSN: 0971-5916 [Print] India
• PMID: 25027089 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Immunoglobulin G
• Immunoglobulin M
• Measles-Mumps-Rubella Vaccine

Topics

• Adult
• Antibodies, Viral (blood)
• Child
• Drug-Related Side Effects and Adverse Reactions (epidemiology, pathology)
• Female
• Humans
• Immunoglobulin G (blood)
• Immunoglobulin M (blood)
• India
• Male
• Measles (epidemiology, prevention & control)
• Measles-Mumps-Rubella Vaccine (administration & dosage, adverse effects, blood)
• Mumps (epidemiology, prevention & control)
• Rubella (epidemiology, prevention & control)
• Young Adult