Number of polyploid giant cancer cells and expression of EZH2 are associated with VM formation and tumor grade in human ovarian tumor.

Abstract

To investigate the associations among the number of polyploid giant cancer cells (PGCCs) and vasculogenic mimicry (VM), EZH2 expression, and serous ovarian tumor grade, a total of 80 paraffin-embedded serous ovarian tumor samples including 21 cases of primary carcinoma and their metastatic tumors, 26 cases of primary carcinoma without metastasis, and 12 cases of serous borderline cystadenoma were analyzed. PGCCs and VM were detected in human serous ovarian tumor. The metastatic foci of ovarian carcinoma had the highest number of PGCCs and VM. The number of PGCCs and VM increased with the grade of ovarian carcinomas. PGCCs generated erythrocytes via budding and together they formed VM. Tumor cells and cancer-associated fibroblasts were positive for EZH2 immunohistochemical staining. The tumor cells and cancer associated fibroblasts in the metastatic foci had the highest staining index of EZH2 staining. Both tumor cells and cancer-associated fibroblasts express EZH2 which then contributes to the malignant grade of serous ovarian tumor.

• Authors: Li Zhang, Po Ding, Hongcheng Lv, Dan Zhang, Guang Liu, Zhengduo Yang, Yan Li, Jun Liu, Shiwu Zhang
• Journal: BioMed research international (Biomed Res Int) Vol. 2014 Pg. 903542 ( 2014) ISSN: 2314-6141 [Electronic] United States
• PMID: 25025074 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• EZH2 protein, human
• Enhancer of Zeste Homolog 2 Protein
• Polycomb Repressive Complex 2

Topics

• Carcinoma (genetics, pathology)
• Cell Count
• Cell Line, Tumor
• Cystadenoma, Serous (genetics, pathology)
• Enhancer of Zeste Homolog 2 Protein
• Female
• Gene Expression Regulation, Neoplastic (genetics)
• Giant Cells (metabolism, pathology)
• Humans
• Neoplasm Grading
• Neoplasm Metastasis
• Neovascularization, Pathologic (genetics, pathology)
• Ovarian Neoplasms (genetics, pathology)
• Polycomb Repressive Complex 2 (biosynthesis)
• Polyploidy