Abstract |
Prion protein gene mutations have been associated with clinical pictures mimicking neurodegenerative diseases different from inherited prion diseases (IPD). We report a novel missense P39L mutation in the N-terminal domain of prion protein in 2 patients affected by frontotemporal lobar degeneration syndrome, negative for mutations in genes causative of dementia. Neither the first carrier, a 67-year-old male in which the onset was a progressive non- fluent aphasia, nor the second carrier, a 78-year-old male affected by frontotemporal dementia and parkinsonism, showed any clinical or instrumental findings suggestive of IPD. Genetic screening of healthy controls and in silico analysis provide support for the potential pathogenicity of this variant. Patient phenotypes, unclassifiable as prion disease, may depend on the location of the mutation in the N-terminal domain, outside the amyloid core of pathologic prion protein, although further functional studies are required to determine whether and how this mutation exerts its pathogenic effect. However, genetic screening of prion protein gene becomes relevant in familial degenerative dementia, particularly in geographical areas with high IPD prevalence.
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Authors | Livia Bernardi, Chiara Cupidi, Francesca Frangipane, Maria Anfossi, Maura Gallo, Maria Elena Conidi, Franca Vasso, Rosanna Colao, Gianfranco Puccio, Sabrina A M Curcio, Maria Mirabelli, Alessandra Clodomiro, Raffaele Di Lorenzo, Nicoletta Smirne, Raffaele Maletta, Amalia C Bruni |
Journal | Neurobiology of aging
(Neurobiol Aging)
Vol. 35
Issue 11
Pg. 2657.e7-2657.e11
(Nov 2014)
ISSN: 1558-1497 [Electronic] United States |
PMID | 25022973
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Female
- Frontotemporal Lobar Degeneration
(diagnosis, genetics)
- Genetic Association Studies
- Genetic Testing
- Humans
- Male
- Middle Aged
- Mutation, Missense
- Prions
(genetics)
- Protein Structure, Tertiary
(genetics)
- Syndrome
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