A new combined therapy for functional organ preservation and survival in lateral oropharyngeal wall cancer.

Abstract

CONCLUSION:

The outcome of this treatment was good, indicating that it is safe and effective. A favorable outcome was obtained, especially in patients with T3, N0-1, and N2a-b cancer, while outcome remained unfavorable in patients with T4a and N2c cancer. Consideration should be given to the need for intensity-modulated radiation therapy (IMRT) and maintenance therapy.

OBJECTIVE:

To improve the survival and functional organ preservation rates in patients with lateral oropharyngeal squamous cell carcinoma.

METHODS:

The primary site was treated conservatively by neoadjuvant chemotherapy and/or concurrent chemoradiation therapy. Chemotherapy was administered by superselective intra-arterial infusion and cervical lymph node metastasis was treated by radical neck dissection.

RESULTS:

Among 71 patients, the 5- and 10-year overall survival rates were 85.1% and 63.5%, respectively; and the 5- and 10-year functional organ preservation rates were 61.0% and 51.6%, respectively. The outcomes were especially good in patients with T3 N0-1, and N2a-b cancer. All patients with N2c cancer had poor outcomes.

• Authors: Tohru Furusaka, Akira Matsuda, Akane Tanaka, Hiroshi Matsuda, Takeshi Asakawa, Shuntaro Shigihara
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 134 Issue 8 Pg. 872-80 (Aug 2014) ISSN: 1651-2251 [Electronic] England
• PMID: 25022796 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (mortality, physiopathology, therapy)
• Combined Modality Therapy
• Deglutition (physiology)
• Female
• Follow-Up Studies
• Humans
• Japan (epidemiology)
• Male
• Middle Aged
• Oropharyngeal Neoplasms (mortality, physiopathology, therapy)
• Oropharynx (physiopathology)
• Prognosis
• Retrospective Studies
• Survival Rate (trends)