[Effectiveness of tobramycin and immunologic preparations in experimental Pseudomonas infection].

Abstract

Certain indices of immunity were studied in mice with burn sepsis due to P. aeruginosa during their treatment with tobramycin (Tb) alone or in combination with immunological drugs. The most significant stimulation of the phagocytic function of peritoneal macrophages was observed when Tb was used in combination with polyvalent corpuscular vaccine of P. aeruginosa. When Tb was used alone or in combination with hyperimmune plasma of P. aeruginosa there was observed close correlation between the phagocytic index and the levels of cyclic adenosine-3',5'-monophosphate in them. Therapy of P. aeruginosa infection with the antibiotic and immunological drugs resulted in much higher levels of agglutinine antibodies in blood serum of the mice than the therapy with Tb alone.

• Authors: V V Minukhin, A Ia Tsyganenko
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 34 Issue 4 Pg. 282-6 (Apr 1989) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' tobramitsina i immunopreparatov pri eksperimental'noĭ sinegnoinoĭ infektsii.
• PMID: 2502083 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Bacterial Vaccines
• Immune Sera
• Tobramycin

Topics

• Animals
• Bacterial Vaccines (therapeutic use)
• Burns (complications)
• Combined Modality Therapy
• Female
• Immune Sera
• Immunization, Passive
• Macrophages (immunology)
• Male
• Mice
• Phagocytosis
• Pseudomonas Infections (etiology, immunology, therapy)
• Pseudomonas aeruginosa (immunology)
• Tobramycin (therapeutic use)
• Wound Infection (etiology, immunology, therapy)