[A multicenter comparative study in patients with liver metastasis to compare tegafur in new forms with existing drugs. SF-RC.SF-SP Comparative Study Group].

Abstract	A multicenter comparative study was carried out in 101 patients with liver metastasis to compare tegafur in a new oral form (Sunfural S) and tegafur in a new soft-capsule suppository form (Sunfural Rectal Capsules) with existing drugs. Sunfural S showed a tendency toward high plasma and tissue levels as compared to existing drugs, and clinically, Sunfural S produced survival times that surpassed those of existing drugs. Liver metastasis at the present time has few effective treatments, but we expect that anticancer effects will be obtained through the administration of new drugs with improved bioavailability.
Authors	A Kashii, H Kogure
Journal	Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 7 Pg. 2387-92 (Jul 1989) ISSN: 0385-0684 [Print] Japan
PMID	2502074 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article, Multicenter Study)
Chemical References	Capsules Suppositories Tegafur
Topics	Administration, Oral Adult Aged Aged, 80 and over Biological Availability Capsules Colonic Neoplasms Female Humans Liver (metabolism) Liver Neoplasms (drug therapy, metabolism, secondary) Male Middle Aged Multicenter Studies as Topic Stomach Neoplasms Suppositories Tegafur (administration & dosage, pharmacokinetics, therapeutic use)

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