Inhibition of cell proliferation, migration and invasion of B16-F10 melanoma cells by α-mangostin.

Abstract

In this study, we have evaluated the potential antineoplastic effects of α-mangostin (α-M), the most representative xanthone in Garcinia mangostana pericarp, on melanoma cell lines. This xanthone markedly inhibits the proliferation of high-metastatic B16-F10 melanoma cells. Furthermore, by deeply analyzing which steps in the metastatic process are influenced by xanthone it was observed that α-M strongly interferes with homotypic aggregation, adhesion, plasticity and invasion ability of B16-F10 cells, probably by the observed reduction of metalloproteinase-9 activity. The antiproliferative and antimetastatic properties of α-M have been established in human SK-MEL-28 and A375 melanoma cells. In order to identify pathways potentially involved in the antineoplastic properties of α-M, a comparative mass spectrometry proteomic approach was employed. These findings may improve our understanding of the molecular mechanisms underlying the anti-cancer effects of α-M on melanoma.

• Authors: Simone Beninati, Serafina Oliverio, Martina Cordella, Stefania Rossi, Cinzia Senatore, Immacolata Liguori, Alessandro Lentini, Lucia Piredda, Claudio Tabolacci
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 450 Issue 4 Pg. 1512-7 (Aug 08 2014) ISSN: 1090-2104 [Electronic] United States
• PMID: 25019992 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014. Published by Elsevier Inc.

Chemical References

• Xanthones
• mangostin

Topics

• Animals
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Melanoma, Experimental (pathology)
• Mice
• Neoplasm Invasiveness (prevention & control)
• Neoplasm Metastasis (prevention & control)
• Xanthones (pharmacology)