The diagnostic efficacy of nectin 4 expression in ovarian cancer patients.

Abstract

CONTEXT:

Nectin 4 plays a significant role in cancer cell growth and invasion.

OBJECTIVE:

To explore its diagnostic role in ovarian cancer.

MATERIALS AND METHODS:

Evaluation of nectin 4 expression in ovarian biopsies by real-time PCR and serum nectin 4 and CA-125 by ELISA in 39 ovarian cancer patients, 21 females with benign ovarian neoplasms and 25 control females.

RESULTS:

Nectin 4 expression was significantly higher in ovarian cancer patients and it was significantly correlated to serum nectin 4 and CA-125.

CONCLUSIONS:

Ovarian tissue expression and serum nectin 4 appear to be potential markers in ovarian cancer.

• Authors: Enas Samir Nabih, Fayda Ibrahim Abdel Motaleb, Fekria Ahmed Salama
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 19 Issue 6 Pg. 498-504 (Sep 2014) ISSN: 1366-5804 [Electronic] England
• PMID: 25019423 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Cell Adhesion Molecules
• RNA, Messenger
• nectin4 protein, human

Topics

• Adult
• Aged
• Biomarkers, Tumor (blood)
• Case-Control Studies
• Cell Adhesion Molecules (blood, genetics)
• Female
• Humans
• Middle Aged
• Neoplasms, Cystic, Mucinous, and Serous (blood)
• Ovarian Neoplasms (blood)
• RNA, Messenger (genetics, metabolism)
• ROC Curve